Weight based dosing example

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    • Type: Change Request
    • Resolution: Persuasive with Modification
    • Priority: Medium
    • FHIR Core (FHIR)
    • STU3
    • Pharmacy
    • MedicationRequest
    • Hide

      1. MedRequest0316 - change rateQuantity to a rateRatio - 1.8 mg/kg over 20 min

      2. MedRequest0316 - Fix denominator to 20 minutes in text and xml

      Changes agreed to from WGM - January 2018For example, a base solution is D5W with bag volume = 500mL, Rate = 7.5ml/hr, infuse over 33.3 hours. Patient weight is 50 KG. Additive is Dopamine, 400mg, to be given at a rate of 4 mcg/kg/min, which for this specific patient would be 200 mcg/min.

      · Example 1

      MedicationRequest.supportingInformation = weight Observation of 50kg

      MedicationRequest.medication.ingredient.amount (D5W) = 500mL

      timing.repeat.duration = 33.3 hours

      rateQuantity = 4cmg/kg/min

      ·

      · Example 2

      MedicationRequest.medication.ingredient.amount (D5W) = 500mL

      timing.repeat.duration = 33.3 hours

      rateQuantity = 200 mcg/min

      ·

      · Example 3

      MedicationRequest.supportingInformation = weight Observation of 50kg

      MedicationRequest.medication.ingredient.amount (D5W) = 500mL

      timing.repeat.duration = 33.3 hours

      rateQuantity = 7.5 ml/hr

      doseQuantity = 400mg

      Show
      1. MedRequest0316 - change rateQuantity to a rateRatio - 1.8 mg/kg over 20 min 2. MedRequest0316 - Fix denominator to 20 minutes in text and xml Changes agreed to from WGM - January 2018For example, a base solution is D5W with bag volume = 500mL, Rate = 7.5ml/hr, infuse over 33.3 hours. Patient weight is 50 KG. Additive is Dopamine, 400mg, to be given at a rate of 4 mcg/kg/min, which for this specific patient would be 200 mcg/min. · Example 1 MedicationRequest.supportingInformation = weight Observation of 50kg MedicationRequest.medication.ingredient.amount (D5W) = 500mL timing.repeat.duration = 33.3 hours rateQuantity = 4cmg/kg/min · · Example 2 MedicationRequest.medication.ingredient.amount (D5W) = 500mL timing.repeat.duration = 33.3 hours rateQuantity = 200 mcg/min · · Example 3 MedicationRequest.supportingInformation = weight Observation of 50kg MedicationRequest.medication.ingredient.amount (D5W) = 500mL timing.repeat.duration = 33.3 hours rateQuantity = 7.5 ml/hr doseQuantity = 400mg
    • Michelle/Danielle: 7-0-0
    • Enhancement
    • Non-substantive
    • STU3

      Multiple issues/questions:
      1) http://build.fhir.org/medicationrequest0316.xml.html shows a rateQuantity = 20 minutes, which seems incorrect since 20 minutes is more like it is the infuse over time period (i.e. timing.repeat.duration). The spec says "when rate doesn't imply duration (e.g. 250mL/hour), then the timing.repeat.duration is needed to convey the infuse over time period"
      2) The same example has dosageInstructions.text = "1.8 mg/kg IV infusion over 30 minutes every 3 weeks for 16 cycles" – which seems inconsistent to say infuse over 30 minutes in the text, but then show 20 minutes in the structured data.
      3) I'd like to see an example for weight-based dosing and/ confirmation of the right way to represent the rate and doseQuantity from the example in https://gforge.hl7.org/gf/project/fhir/tracker/?action=TrackerItemEdit&tracker_item_id=8345 MedicationRequest ordered for a patient with weight of 50 kg. Base solution is D5W with bag volume = 500mL, Rate = 7.5ml/hr, infuse over 33.3 hours. Additive is Dopamine, 400mg, to be given at a rate of 4 mcg/kg/min, which for this specific patient would be 200 mcg/min.
      * The prior tracker suggested that rate = active ingredient rate (200 mcg/min), but it could also be the bag rate (7.5ml/hr) – is there guidance on which is correct or preferred?
      * doseQuantity is more controversial with the suggested 4 mcg/kg/min (since this feels like an alternative way to represent rate). Shouldn't the doseQuantity be more like 400 mg (= 4mcg/kg/min * 50 kg * 33.3 hours * 60 min/hr)?

            Assignee:
            Unassigned
            Reporter:
            Michelle Miller
            Watchers:
            1 Start watching this issue

              Created:
              Updated:
              Resolved: