Revise answer list for Genotype Medication Efficacy Impact profile (LOINC 51961-1)

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    • Type: Change Request
    • Resolution: Persuasive with Modification
    • Priority: Medium
    • Genomics Reporting (FHIR)
    • STU3
    • Clinical Genomics
    • (profiles) [deprecated]
    • 2.28
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      Persuasive with Mod

      On the LOINC code, change Benign to Non-Responsive. Remove Presumed Benign. Mention on the answer list that this is from the variants effect on the drug. Add guidance for the answers.

      Refer to this profile for things like "increase/descrease dosage" as a possible candidate: http://build.fhir.org/ig/HL7/genomics-reporting/task-med-chg.html

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      Persuasive with Mod On the LOINC code, change Benign to Non-Responsive. Remove Presumed Benign. Mention on the answer list that this is from the variants effect on the drug. Add guidance for the answers. Refer to this profile for things like "increase/descrease dosage" as a possible candidate: http://build.fhir.org/ig/HL7/genomics-reporting/task-med-chg.html
    • Kevin P / Julian S: 11-0-0
    • Enhancement
    • Non-compatible

      Would like to review this value set and potentially revise it. I find the set of values confusing, not sure which value to select in some cases. For instance, Genotype AT at rs17244841 (HMGCR gene) is associated with a decreased response to simvastatin - what LOINC answer should be used? (See listserver thread "Value set for Genotype Medication Efficacy Impact 51961-1", particularly Shennon's email on March 5 which provides a very nice summary of considerations and options).

            Assignee:
            Unassigned
            Reporter:
            Bob Dolin
            Watchers:
            1 Start watching this issue

              Created:
              Updated:
              Resolved: