Remove all current Implication profiles except abstract base, add 2 new profiles restructuring our current components and codes as Diagnostic Implication and Therapeutic Implication   Genomic Implication Profile Extension: RelatedArtifact (0..*)   derivedFrom (reference: Observation/Variant/Haplotype/Genotype) (1..*)   Component: 93044-6 | Level of Evidence / “clinical validity” (0..1) Binding*:* LOINC Answer List LL5356-2 ( preferred )   Component: TBD code | prognosis (0..1) E.g. Better outcome, poorer outcome Binding*:* (unbound) ( example )     Diagnostic Implication Profile code: TBD code | Diagnostic implication   Value 0..0   Component: 53037-8 | LL4034-6 (clinical significance) (0..1) Pathogenic | Likely pathogenic | Uncertain significance | Likely benign | Benign Binding*:* LOINC Answer List LL4034-6 ( extensible )   Component: 81259-4 | (Associated phenotype) (0..*) Binding*:* (unbound) ( example )   Component: TBD code | (Associated cancer) (0..*) Binding*:* (unbound) ( example )   Component 79742-3 | LL3731-8 (Mode of inheritance) (0..1) Autosomal dominant|Autosomal recessive|X-linked dominant|X-linked recessive|Y-linked|Codominant|Mitochondrial Binding: LOINC Answer List LL3731-8 ( preferred )     Therapeutic Implication Profile   code: TBD | Therapeutic implication   Value 0..0   Component: 81259-4 | (Associated phenotype) (0..*) Binding*:* (unbound) ( example )   Component: TBD code | (Associated cancer) (0..*) Binding*:* (unbound) ( example )   Component: 51963-7 |  (medication-assessed) (0..*) Binding*:* (unbound) ( example )   Component: TBD |  (therapy-assessed) (0..*) Binding*:* (unbound) ( example )   Component: 53040-2 |  (effect-medication-metabolism) (0..1) Ultrarapid metabolizer | Rapid metabolizer | Normal metabolizer | Intermediate metabolizer | Poor metabolizer Binding*:* LOINC Answer List LL3856-3 ( preferred )   Component: 83009-1 | (effect-medication-high-risk) (0..1) Low risk | High risk Binding*:* LOINC Answer List LL2353-2 ( extensible )   Component: TBD | (effect-medication-transporter) (0..1) Increased function | Normal function | Decreased function | Poor function Binding*:* (unbound) ( example )   Component: 51961-1 | LL3856-3 (effect-medication-efficacy) (0..1) Resistant | Responsive | Presumed resistant | Presumed responsive | Unknown significance | Non-Responsive | Presumed non-responsive Binding*:* LOINC Answer List LL539-8 ( preferred )