Existing Wording: It avoids pre-coordinating the type of variant, medication or other information into the Observation.code as this makes it easier to leverage industry standard terminologies for genetic information (e.g. HGVS) and avoids needing to duplicate this information into observation coding systems such as LOINC.

Comment:

In principle, avoiding pre-coordination is crucial to the usability of our specification for analytics. Pre-coordinating a bio-marker into an observation.code is perhaps the extreme case. But also, including observation components holding information pertaining to the observation.value is also a type of pre-coordination, which should be avoided as well, for example, interpretation, relevance, or any type of downstream analysis. HGVS is different in that it?s a notation rather than terminology but still - an HGVS should be post-coordinated in order to disambiguate the genomic information in an HGVS expression, as well as separate its clinical aspects in a post-coordination fashion.

Summary:

pre-coordination