http://build.fhir.org/sequence.html

Currently has this note:

At present, the Sequence resource is multi-purpose. It can be used to represent a "definitional" sequence, as might be found in a knowledge-base source in a patient- and specimen-independent manner. It can also be used to represent information about a specific finding when testing a specimen, including qualifying information about confidence, uncertainty, etc. The Clinical Genomics workgroup is considering modifying the resource to be definition-only, removing the ability to convey patient, specimen and observation-specific information. Such data elements would instead be conveyed using the Observation resource, as this is more typically used in the lab setting to report patient-specific results. The Sequence resource would be retained for sharing of genetic knowledge, such as reference sequences, quality metrics, and links to external repository sequences. Feedback about this proposed change is welcome.

_For insight into what the new approach to representing patient-specific genetic information, refer to the Implementation Guide (IG) for clinical genomics reporting, which can be found [here

Given the track here https://gforge.hl7.org/gf/project/fhir/tracker/?action=TrackerItemEdit&tracker_item_id=16252, we have for now decided to not make Sequence definitional. However, the remaining pieces have not been approved or denied. Seems we should update the note in someway.