Would be better if the GeneticVariantFound profile more closely followed the Variant profile from the Clinical Genomics Working Group: http://build.fhir.org/ig/HL7/genomics-reporting/obs-variant.html Realize that it has many optional component observations and you would likely want to sub select. It would be important to carry the property that provides codes for the variant via multiple alternate coding systems. Also realize that different profiles exist for pharacogenomics, drug and prognostic implications for somatic variants. The working group is still finalizing some of them. See here for an overvall UML: http://build.fhir.org/ig/HL7/genomics-reporting/sequencing.html Not suggesting that you follow it compulsively but it has most of what you need (and maybe more than you need).