Comment:

Comment only. I leave it to the oncologists consulted in this project as to weather or not the annotation associated with the finding of a variant (e.g. interpretation of the presence of a variant with respect to Tumor treatment outcome) is needed in the MINIMAL data set. The current offering of discrete variant results is sufficient, if one considers use of the variant data by recipient applications to reprobe algorithms or knowledge bases for annotations. Would consider mentioning why the absence of genetic-annotation information in the Profile description.

Summary:

Is annotation of the finding of a variant needed in a minimal data set?